Jul 18, 2012
Problems with belly fat? PaleoPharm now offers its DNA Gourmet ® brand nutraceutical, Optimized Green Coffee Bean Extract (GCBE), that contains green coffee bean extract (chlorogenic acid) with a small amount of caffeine (less than that found in a cup of coffee or tea) to synergistically promote fat loss and support health blood sugar levels. DNA Gourmet ® offers only the highest quality pure green coffee bean extract available.
DNA Gourmet® Optimized Green Coffee Bean Extract
Evidence is accumulating from animal studies and human clinical trials that green coffee bean extract (GCE) could play an important role in the war on obesity. Investigators involved in a recently published human clinical trial concluded that “results suggest that GCE [green coffee bean extract] may be an effective nutraceutical in reducing weight in preobese adults, and may be an inexpensive means of preventing obesity in overweight adults.”
Specifically, this 2012 randomized, double-blind placebo-controlled human study (the gold standard of evidence-based medical studies), found that GCE, which contains a small amount of caffeine (less than that found in half a cup of coffee), was a safe-and-effective synergistic combination nutraceutical for reducing body weight in adults. GCE produced an average weight loss of 17.6 pounds per person in study participants classified as pre-obese even though they did not attempt to diet or lose weight. More than one-third of study participants were able to lose 10.7% of their body fat to be re-classified as normal weight. Really?
No-Spin Analysis and Opinion
Although Dr. Mehmet has enthusiastically endorsed the fat-loss potential of GCE on his TV show, I am not quite as enthusiastic about the results of the human clinical trial Dr. Oz relied upon to fuel his excitement, although a number of published pre-clinical studies support the efficacy of GCE.
The human trial testing GCE suffered from numerous design and statistical analysis flaws. Importantly, the study data show that test subjects lost an appreciable amount of body weight with no reported decrease in caloric intake. This suggests that the method used to gather diet data (dietary recall, a technique which is subject to human recall error) was flawed. Also, subjects in the high-dose, low-dose, and placebo arms of the study all showed similar loss of body fat while the placebo arm didn’t show any change in body weight. Just as problematic, study participants continued to lose weight during the washout period when they weren’t taking GCE. Regrettably, the potentially flawed methodology of dietary recall doesn’t allow us to accurately gauge the dietary intake of each group.
This doesn’t mean that GCE isn’t an effective fat-loss, appetite suppressant, or blood sugar aid; it simply means that the human study that Dr. Oz relied upon has too many faults to tell us, one way or the other, just how effective GCE really is. Other data suggest that GCE is a promising weapon in the war on obesity.
Collectively, the data on GCE suggest that it is a good candidate for promoting thermogenesis on the order of another natural nutraceutical, green tea extract, while it also helps inhibit intestinal absorption of sugar and promotes skeletal muscle uptake of sugar to be burned for energy.
Weight-loss results of GCE appear to be similar to those of the latest FDA-approved prescription weight-loss drug but without the serious and evening life-threatening events linked to this drug. Check out this informative article and my post to learn more about the possible side effects of the newest prescription weight-loss medicine.
Importantly, published studies have found that the bioactive ingredient in green coffee beans, chlorogenic acid, might support healthy blood pressure in humans and in laboratory animals (see here and here). Anecdotal evidence suggests a possible diuretic effect, which could account for all or part of the antihypertensive effect of GCE. Research also suggests this antihypertensive action could be due to the fact that GCE contains chlorogenic acid as a major phenolic compound, and chlorogenic acid contains ferulic acid as a metabolic component that acts on nitric oxide (NO) in the vascular endothelium. GCE may thus promote relaxation of blood vessels, by increasing expression of NO, thereby supporting healthy blood pressure.
Research scientists have postulated that GCE can support healthy glucose tolerance in humans. Studies suggest that this effect could be accomplished by promoting the absorption of glucose from the distal, rather than the proximal part of the gastrointestinal tract, thereby supporting blood sugar levels in the normal range.
DNA Gourmet ® Optimized Green Coffee Bean Extract contains a clinically tested dose of chlorogenic acid plus a small amount of synergistic caffeine (20 mg–less than the amount in ½ cup of coffee) per capsule. This nutraceutical product is ideally suited for those following a low-carbohydrate or Paleo diet or those following a CR (calorie-restricted) life-extension-type diet who want to reduce glycation, control insulin and blood sugar levels, and lose additional body fat.
What You Need To Know
Studies suggest that the use of GCE:
- Promotes loss of body fat independently of diet and exercise
- Supports healthy blood pressure
- Supports healthy blood glucose levels
- Favorably modulates gene expression involved in insulin signaling
Warning: This product is not recommended for pregnant or nursing mothers, children under 18, or anyone with a medical condition or an allergy or sensitivity to any of the components in the product.
Why Green Coffee Beans Rather Than Roasted Beans?
The normal roasting processing of the coffee you drink destroys much of the beneficial phenolic content of the coffee bean.
Green coffee bean extract, derived from green coffee beans, contains the bioactive nutraceutical, chlorogenic acid. Chlorogenic acid has been shown to inhibit excessive activity of glucose-6-phosphatase, an enzyme that triggers glucose formation from glycogen release from the liver and from non-carbohydrate substrates, both of which can increase blood glucose levels.
Studies suggest that green coffee bean extract supports healthy after-meal glucose levels is by inhibiting the alpha-glucosidase enzyme in the intestine that breaks down complex sugars and enhances their absorption into the bloodstream.
Human trials suggest that green coffee bean extract can promote fat loss in people who don’t intentionally restrict calories or increase physical activity, however it is suggested that this product works optimally when used as a part of a healthy, reduced-calorie diet and exercise program.